PD-173955

CAT: 0013-GTR19159801-07Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19159801-07Size:25 mg

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Description

PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G (1) . PD173955 has an IC (50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC (50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC (50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC (50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC (50) = 1 microM) -dependent cell growth.

CAS Number

260415-63-2

Product Name Alternative

PD173955 | PD 173955

Purity

>98% (HPLC)

Solubility

DMSO : ≥ 32 mg/mL; 72.18 mM

Smiles

CSc1cccc (Nc2ncc3cc (c (=O) n (C) c3n2) c2c (Cl) cccc2Cl) c1

Molecular Formula

C21H16Cl2N4OS

Molecular Weight

443.35

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

6- (2,6-dichlorophenyl) -8-methyl-2- ((3- (methylthio) phenyl) amino) pyrido[2,3-d]pyrimidin-7 (8H) -one

Chemical Information

PD173955

PD173955 is a dichlorobenzene, an aryl sulfide, a pyridopyrimidine and a methyl sulfide. It has a role as a tyrosine kinase inhibitor.

CAS Number	260415-63-2
PubChem CID	447077
IUPAC Name	6-(2,6-dichlorophenyl)-8-methyl-2-(3-methylsulfanylanilino)pyrido[2,3-d]pyrimidin-7-one
Molecular Formula	C21H16Cl2N4OS
Molecular Weight	443.3
XLogP	5.4
Topological Polar Surface Area	83.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Heavy Atom Count	29
Formal Charge	0
Complexity	626

SMILES

CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC=C3Cl)Cl)NC4=CC(=CC=C4)SC

InChI

InChI=1S/C21H16Cl2N4OS/c1-27-19-12(9-15(20(27)28)18-16(22)7-4-8-17(18)23)11-24-21(26-19)25-13-5-3-6-14(10-13)29-2/h3-11H,1-2H3,(H,24,25,26)

InChIKey

VAARYSWULJUGST-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 260415-63-2

CID: 447077

Formula: C21H16Cl2N4OS

MW: 443.3

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	443.3
XLogP3	5.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	442.0421877
Monoisotopic Mass	442.0421877
Topological Polar Surface Area	83.4 Å²
Heavy Atom Count	29
Formal Charge	0
Complexity	626
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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GTR19230432-01	PD-1/PD-L1-IN-32
GTR19218734-01	PD-1/PD-L1-IN-34
GTR19183553-01	PD-1/PD-L1-IN-9
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GTR19262200-01	PD-1/PD-L1-IN-41
GTR19261585-01	PD-1/PD-L1-IN-40
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Alternative Products

Catalog	Name
406164	PD-173955
sc-507378	PD 173955
MBS130571-01	PD 173955,
KHA03999-01	PD 173955-Analog1
GW8987-1mg	PD-173955-Analog1
HY-18298	PD 173955 analog 1
SC1063-5mg	PD-173955 (Bcr-Abl inhibitor)
HY-144649	PD-1/PD-L1-IN-24
T209760-01	PD-1/PD-L1-IN-43
T208964-01	PD-1/PD-L1-IN-40

PD-173955

Chemical Information

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