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PD-173955

CAT: 0013-GTR19159801-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159801-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G (1) . PD173955 has an IC (50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC (50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC (50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC (50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC (50) = 1 microM) -dependent cell growth.
CAS Number
260415-63-2
Product Name Alternative
PD173955 | PD 173955
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 32 mg/mL; 72.18 mM
Smiles
CSc1cccc (Nc2ncc3cc (c (=O) n (C) c3n2) c2c (Cl) cccc2Cl) c1
Molecular Formula
C21H16Cl2N4OS
Molecular Weight
443.35
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6- (2,6-dichlorophenyl) -8-methyl-2- ((3- (methylthio) phenyl) amino) pyrido[2,3-d]pyrimidin-7 (8H) -one

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