Products for Research Use Only
RegisterLogin

Encorafenib

CAT: 0013-GTR19159726-01Size: 100 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19159726-01Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Encorafenib, also known as LGX-818, is an orally available Raf kinase inhibitor with potential antineoplastic activity. LGX818 specifically inhibits Raf kinase, a serine/threonine enzyme in the RAF/mitogen-activated protein kinase kinase (MEK) /extracellular signal-related kinase (ERK) signaling pathway. By inhibiting the activation of the RAF/MEK/ERK signaling pathway, the administration of LGX818 may result in a decrease in proliferation of tumor cells. (In Vitro) :Encorafenib (LGX818) is a potent drug that can prevents diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf. Encorafenib (LGX818) (10 nM) suppresses the ERK/MAPK pathway and displays marked inhibition of pERK in A375, G361 and SK-MEL-24 cells. 10 nM Encorafenib (LGX818) treatment for 12 days potently inhibits colony formation in A375, G361 and SK-MEL-24 cells, but not in RPMI7951 and C8161 cells. Encorafenib (LGX818) treatment induces a steady increase in the β-catenin level in G361 cells over time.
CAS Number
1269440-17-6
Product Name Alternative
LGX818 | LGX-818 | LGX 818 | Encorafenib
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO : 50 mg/mL 92.59 mM
Smiles
C[C@@H] (CNC1=NC=CC (=N1) C2=CN (N=C2C3=CC (=CC (=C3F) NS (=O) (=O) C) Cl) C (C) C) NC (=O) OC
Molecular Formula
C22H27ClFN7O4S
Molecular Weight
540.01
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(S) -methyl (1- ((4- (3- (5-chloro-2-fluoro-3- (methylsulfonamido) phenyl) -1-isopropyl-1H-pyrazol-4-yl) pyrimidin-2-yl) amino) propan-2-yl) carbamate.

Alternative Products

CatalogName
T6487-01Encorafenib
RM-E225006-01Encorafenib Impurity 6 (R-Isomer Encorafenib)
TRC-E348006-10MGEncorafenib d7
AR-E09816-01Encorafenib-d7
HY-15605R-01Encorafenib (Standard)
CS-O-44796Encorafenib-d8

Popular Products