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Encorafenib (Standard)

CAT: 0804-HY-15605R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15605R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Encorafenib (Standard) is the analytical standard of Encorafenib. This product is intended for research and analytical applications. Encorafenib (LGX818) is a highly potent BRAF inhibitor with selective anti-proliferative and apoptotic activity in cells expressing BRAFV600E (EC50=4 nM) .
CAS Number
1269440-17-6
Product Name Alternative
LGX818 (Standard)
UNSPSC
12352005
Target
Raf; Reference Standards
Type
Reference Standards
Related Pathways
MAPK/ERK Pathway; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/encorafenib-standard.html
Smiles
O=C(OC)N[C@@H](C)CNC1=NC=CC(C2=CN(C(C)C)N=C2C3=CC(Cl)=CC(NS(=O)(C)=O)=C3F)=N1
Molecular Formula
C22H27ClFN7O4S
Molecular Weight
540.01
References & Citations
[2]Li Z, et al. Encorafenib (LGX818), a potent BRAF inhibitor, induces senescence accompanied by autophagy in BRAFV600E melanoma cells. Cancer Lett. 2016 Jan 28;370 (2) :332-44.|[1]Compounds and compositions as protein kinase inhibitors . Patent WO 2011025927 A1
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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