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LM10

CAT: 0013-GTR19159699-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19159699-01Size:1 g
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Description
LM10 is a selective tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50 values are 0.62 and 2 μM for human and mouse TDO, respectively) . LM10 exhibits selectivity for TDO over IDO, MAO-A, MAO-B, and a panel of receptors and transporters. LM10 reduces growth of TDO-expressing P815 mastocytoma tumors in mice.
CAS Number
1316695-35-8
Product Name Alternative
LM10 | LM 10 | LM-10
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 50 mg/mL (218.14 mM)
Smiles
Fc2cc3ncc (/C=C/c1nnnn1) c3cc2
Molecular Formula
C11H8FN5
Molecular Weight
229.22
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6-fluoro-3-[ (E) -2- (1H-1,2,3,4-tetrazol-5-yl) ethenyl]-1H-indole

Chemical Information

(E)-3-(2-(1H-Tetrazol-5-YL)vinyl)-6-fluoro-1H-indole
CAS Number1316695-35-8
PubChem CID135743630
IUPAC Name6-fluoro-3-[(E)-2-(2H-tetrazol-5-yl)ethenyl]-1H-indole
Molecular FormulaC11H8FN5
Molecular Weight229.21
XLogP2
Topological Polar Surface Area70.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count17
Formal Charge0
Complexity298
SMILES
C1=CC2=C(C=C1F)NC=C2/C=C/C3=NNN=N3
InChI
InChI=1S/C11H8FN5/c12-8-2-3-9-7(6-13-10(9)5-8)1-4-11-14-16-17-15-11/h1-6,13H,(H,14,15,16,17)/b4-1+
InChIKey
JDBSZVDIUIRSDG-DAFODLJHSA-N
Chemical Structure
2D Structure
2D structure of (E)-3-(2-(1H-Tetrazol-5-YL)vinyl)-6-fluoro-1H-indole
CAS: 1316695-35-8
CID: 135743630
Formula: C11H8FN5
MW: 229.21
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight229.21
XLogP32
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass229.07637344
Monoisotopic Mass229.07637344
Topological Polar Surface Area70.3 Ų
Heavy Atom Count17
Formal Charge0
Complexity298
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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