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ML297

CAT: 0013-GTR19159632-05Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159632-05Size:10 mg
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Description
ML297 is a selective Kir3.1/3.2 (GIRK1/2) channel activator (IC50 values are 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively) . ML297 exhibits no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels, and has minimal effect on a panel of other ion channels, receptors and transporters.
CAS Number
1443246-62-5
Product Name Alternative
ML297 | ML 297 | ML-297
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 250 mg/mL (761.45 mM)
Smiles
Fc1ccc (cc1F) NC (=O) Nc3cc (C) nn3c2ccccc2
Molecular Formula
C17H14F2N4O
Molecular Weight
328.11
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1- (3,4-difluorophenyl) -3- (5-methyl-2-phenylpyrazol-3-yl) urea

Chemical Information

ML297

ML297 is an organic molecular entity. It has a role as a potassium channel opener.

CAS Number1443246-62-5
PubChem CID56642816
IUPAC Name1-(3,4-difluorophenyl)-3-(5-methyl-2-phenylpyrazol-3-yl)urea
Molecular FormulaC17H14F2N4O
Molecular Weight328.32
XLogP3.4
Topological Polar Surface Area59
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count24
Formal Charge0
Complexity433
SMILES
CC1=NN(C(=C1)NC(=O)NC2=CC(=C(C=C2)F)F)C3=CC=CC=C3
InChI
InChI=1S/C17H14F2N4O/c1-11-9-16(23(22-11)13-5-3-2-4-6-13)21-17(24)20-12-7-8-14(18)15(19)10-12/h2-10H,1H3,(H2,20,21,24)
InChIKey
IEKSMUSSYJUQMY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of ML297
CAS: 1443246-62-5
CID: 56642816
Formula: C17H14F2N4O
MW: 328.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight328.32
XLogP33.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass328.11356741
Monoisotopic Mass328.11356741
Topological Polar Surface Area59 Ų
Heavy Atom Count24
Formal Charge0
Complexity433
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
MBS808247-01ML297
217384GIRK Activator, ML297 (1- (3,4-Difluorophenyl) -3- (3-methyl-1-phenyl-1H-pyrazol-5-yl) urea, N- (3,4-Difluorophenyl) -N′- (3-methyl-1-phenyl-1H-pyrazol-5-yl) urea, CID 56642816, VU0456810)

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