DIM-C-pPhOH

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Description

DIM-C-pPhOH is a Nur77 Antagonist. DIM-C-pPhOH inhibits lung cancer cell and tumor growth in a metastasis model. (In Vitro) :DIM-C-pPhOH (7.5-20 μM; 24 hours; ACHN and 786-O cells) treatment significantly decreases cell proliferation.DIM-C-pPhOH (20 μM; 24 hours; ACHN and 786-O cells) treatment induces Annexin V staining in ACHN and 786-O cells, confirming that DIM-C-pPhOH induce apoptosis, and also induces cleavage of caspases 7 and 8.DIM-C-pPhOH (15-20 μM; 24 hours; ACHN and 786-O cells) treatment inhibits NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induces sestrin 2, activates AMPKα and inhibits activation of mTOR and downstream kinases.DIM-C-pPhOH decreases expression of β1-integrin protein and mRNA and β1-integrin-dependent responses in MCF7, MDA-MB-231, and SKBR3 cells and also inhibits migration of the latter two cell lines. (In Vivo) :DIM-C-pPhOH (30 mg/kg; oral gavage; daily; for 50 days; male athymic nude mice) treatment results in a significant inhibition of tumor growth.

CAS Number

151358-47-3

Product Name Alternative

DIM-C-pPhOH

Purity

>98% (HPLC)

Solubility

In Vitro: DMSO : 125 mg/mL (369.39 mM)

Smiles

Oc1ccc (cc1) C (c3cnc2ccccc23) c5cnc4ccccc45

Molecular Formula

C23H18N2O

Molecular Weight

338.41

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

1,1-Bis (3'-indolyl) -1- (p-hydroxyphenyl) methane

Chemical Information

DIM-C-pPhOH

CAS Number	151358-47-3
PubChem CID	2940609
IUPAC Name	4-[bis(1H-indol-3-yl)methyl]phenol
Molecular Formula	C23H18N2O
Molecular Weight	338.4
XLogP	5.2
Topological Polar Surface Area	51.8
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	3
Heavy Atom Count	26
Formal Charge	0
Complexity	443

SMILES

C1=CC=C2C(=C1)C(=CN2)C(C3=CC=C(C=C3)O)C4=CNC5=CC=CC=C54

InChI

InChI=1S/C23H18N2O/c26-16-11-9-15(10-12-16)23(19-13-24-21-7-3-1-5-17(19)21)20-14-25-22-8-4-2-6-18(20)22/h1-14,23-26H

InChIKey

QCPDFNWJBQMXLI-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 151358-47-3

CID: 2940609

Formula: C23H18N2O

MW: 338.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	338.4
XLogP3	5.2
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	1
Rotatable Bond Count	3
Exact Mass	338.141913202
Monoisotopic Mass	338.141913202
Topological Polar Surface Area	51.8 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	443
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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Alternative Products

Catalog	Name
A4644-5	DIM-C-pPhOH
A22424-100	DIM-C-pPhOH 100mg
A22424-25	DIM-C-pPhOH 25mg
A22424-5	DIM-C-pPhOH 5mg
A22424-1	DIM-C-pPhOH 1mg
A22424-200	DIM-C-pPhOH 200mg
A22424-50	DIM-C-pPhOH 50mg
A22424-10	DIM-C-pPhOH 10mg
A22424-2	DIM-C-pPhOH 2mg
6377/25	DIM-C-pPhOH 25 mg

DIM-C-pPhOH

Chemical Information

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