DIM-C-pPhOH

CAT: 0013-GTR19159596-01Size: 500 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19159596-01Size:500 mg

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Description

DIM-C-pPhOH is a Nur77 Antagonist. DIM-C-pPhOH inhibits lung cancer cell and tumor growth in a metastasis model. (In Vitro) :DIM-C-pPhOH (7.5-20 μM; 24 hours; ACHN and 786-O cells) treatment significantly decreases cell proliferation.DIM-C-pPhOH (20 μM; 24 hours; ACHN and 786-O cells) treatment induces Annexin V staining in ACHN and 786-O cells, confirming that DIM-C-pPhOH induce apoptosis, and also induces cleavage of caspases 7 and 8.DIM-C-pPhOH (15-20 μM; 24 hours; ACHN and 786-O cells) treatment inhibits NR4A1-regulated expression of survivin, bcl-2 and EGFR in ACHN and 786-O cells. And also induces sestrin 2, activates AMPKα and inhibits activation of mTOR and downstream kinases.DIM-C-pPhOH decreases expression of β1-integrin protein and mRNA and β1-integrin-dependent responses in MCF7, MDA-MB-231, and SKBR3 cells and also inhibits migration of the latter two cell lines. (In Vivo) :DIM-C-pPhOH (30 mg/kg; oral gavage; daily; for 50 days; male athymic nude mice) treatment results in a significant inhibition of tumor growth.

CAS Number

151358-47-3

Product Name Alternative

DIM-C-pPhOH

Purity

>98% (HPLC)

Solubility

In Vitro: DMSO : 125 mg/mL (369.39 mM)

Smiles

Oc1ccc (cc1) C (c3cnc2ccccc23) c5cnc4ccccc45

Molecular Formula

C23H18N2O

Molecular Weight

338.41

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

1,1-Bis (3'-indolyl) -1- (p-hydroxyphenyl) methane

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DIM-C-pPhOH

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