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Coptisine

CAT: 0013-GTR19159624-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159624-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Coptisine treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . Coptisine treats myocardial I/R likely through suppressing myocardial apoptosis and inflammation by inhibiting the Rho/ROCK pathway. Coptisine is a potential anti-osteosarcoma drug candidate, via exerting a strong anti-osteosarcoma effect with very low toxicity .Coptisine with a high dosage could inhibit cholesterol synthesis via suppressing the HMGCR expression and promoting the use and excretion of cholesterol via up-regulating LDLR and CYP7A1 expression. Coptisine suppresses adhesion, migration and invasion of MDA-MB-231 breast cancer cells in vitro, the down-regulation of MMP-9 in combination with the increase of TIMP-1 possibly contributing to the anti-metastatic function for breast cancer.
CAS Number
3486-66-6
Product Name Alternative
Coptisin
Purity
>98% (HPLC)
Smiles
C1C[N+]2=C (C=C3C=CC4=C (C3=C2) OCO4) C5=CC6=C (C=C51) OCO6
Molecular Formula
C19H14NO4+
Molecular Weight
320.32
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Alternative Products

CatalogName
N1737-20Coptisine
M18873-01Coptisine chloride
N2494-20Coptisine Sulfate
A14548-50Coptisine 50mg
A14548-1Coptisine 1mg
HY-N0736-01Coptisine (chloride)
A14548-25Coptisine 25mg

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