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P-Hydroxy-cinnamic acid

CAT: 0013-GTR19159447-01Size: 1 gDry Ice: NoHazardous: No
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Description
P-Hydroxycinnamic acid can inhibit platelet activity, with IC50s of 371 μM, 126 μM for thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation, respectively. (In Vitro) :p-Hydroxycinnamic acid (p-Coumaric acid), is a ubiquitous plant metabolite with antioxidant and anti-inflammatory properties. p-Hydroxycinnamic acid (500 μM and 1 mM) reduces ADP-induced platelet aggregation (55 2 (SE 4 01) % and 35 6 (SE 2 35) % relative to basal level, respectively) . p-Hydroxycinnamic acid is able to modify platelet function, a shear-inducing device that simulates primary haemostasis. p-Hydroxycinnamic acid interferes also with arachidonic acid cascade, reducing thromboxane B2 production and lipopolysaccharide-induced prostaglandin E2 generation (IC50 371 and 126 μM, respectively) .
CAS Number
7400-08-0
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL; 609.16 mM
Smiles
OC (=O) \C=C\c1ccc (O) cc1
Molecular Formula
C9H8O3
Molecular Weight
164.16
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

P-Coumaric Acid

4-coumaric acid is a coumaric acid in which the hydroxy substituent is located at C-4 of the phenyl ring. It has a role as a plant metabolite. It is a conjugate acid of a 4-coumarate.

CAS Number7400-08-0
PubChem CID637542
IUPAC Name(E)-3-(4-hydroxyphenyl)prop-2-enoic acid
Molecular FormulaC9H8O3
Molecular Weight164.16
XLogP1.5
Topological Polar Surface Area57.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count12
Formal Charge0
Complexity178
SMILES
C1=CC(=CC=C1/C=C/C(=O)O)O
InChI
InChI=1S/C9H8O3/c10-8-4-1-7(2-5-8)3-6-9(11)12/h1-6,10H,(H,11,12)/b6-3+
InChIKey
NGSWKAQJJWESNS-ZZXKWVIFSA-N
Chemical Structure
2D Structure
2D structure of P-Coumaric Acid
CAS: 7400-08-0
CID: 637542
Formula: C9H8O3
MW: 164.16
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight164.16
XLogP31.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass164.047344113
Monoisotopic Mass164.047344113
Topological Polar Surface Area57.5 Ų
Heavy Atom Count12
Formal Charge0
Complexity178
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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