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Chelidonine

CAT: 0013-GTR19159217-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159217-01Size:100 mg
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Description
Chelidonine isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. Chelidonine is a promising model compound for overcoming MDR and for enhancing cytotoxicity of chemotherapeutics, especially against leukaemia cells, its efficacy needs to be confirmed in animal models. Chelidonine may be a potential therapeutic agent against metastasis of invasive human cancer cells, exhibits antimigratory and antiinvasive effects in MDA-MB-231 cells, by suppressing COL-induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent downregulation of IPP downstream signaling molecules, such as Akt and ERK1/2.
CAS Number
476-32-4
Product Name Alternative
Chelidonine | Stylophorin | Khelidonin | Stylophorin
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (282.99 mM)
Smiles
CN1CC2=C (C=CC3=C2OCO3) C4C1C5=CC6=C (C=C5CC4O) OCO6
Molecular Formula
C20H19NO5
Molecular Weight
353.37
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Chelidonine

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