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Yangonin

CAT: 0013-GTR19159154-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159154-01Size:200 mg
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Description
Yangonin is a novel CB receptor ligand, it exhibits affinity for the human recombinant CB receptor. Yangonin could be a valuable candidate for the intervention of NF-κB-dependent pathological conditions such as inflammation. (In Vitro) :Yangonin is one of the six major kavalactones found in Piper methysticum.Yangonin potently inhibits NF-κB activation through suppression of the transcriptional activity of the RelA/p65 subunit of NF-κB. Yangonin significantly inhibits the induced expression of the NF-κB-reporter gene. However, Yangonin does not interfere with TNF-α-induced inhibitor of κBα (IκBα) degradation, p65 nuclear translocation, and DNA-binding activity of NF-κB. Yangonin inhibits not only the induced NF-κB activation by overexpression of RelA/p65, but also transactivation activity of RelA/p65. Yangonin does not inhibit TNF-α-induced activation of p38, but it significantly impairs activation of ERK 1/2 and stress-activated protein kinase/JNK.
CAS Number
500-62-9
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 25 mg/mL (96.80 mM)
Smiles
COC1=CC=C (C=C1) C=CC2=CC (=CC (=O) O2) OC
Molecular Formula
C15H14O4
Molecular Weight
258.27
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Alternative Products

CatalogName
HY-N0919-01Yangonin
HY-W705168Yangonin-d3
271608-01Desmethoxy yangonin

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