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Polyphyllin I

CAT: 0013-GTR19159144-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159144-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax, cytochrome C, and cleaved-caspase-3 levels. Polyphyllin D has an anti-angiogenic effect. Polyphyllin D has toxicity in human RBCs as well as its underlying mechanism for the hemolysis and eryptosis/erythroptosis. Polyphyllin D has strong anticancer activity, can overcome drug resistance in R-HepG2 cells and elicit programmed cell death via mitochondrial dysfunction.
CAS Number
50773-41-6
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (116.96 mM)
Smiles
[C@@H]1 ([C@@H] ([C@@H] ([C@H] ([C@@H] (O1) C) O) O) O) O[C@H]1[C@@H] (O[C@@H] ([C@H] ([C@@H]1O) O[C@@H]1O[C@H] ([C@@H] ([C@H]1O) O) CO) CO) O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@@H]5O[C@@]6 ([C@H] ([C@@H]5[C@]4 (CC[C@@H]3[C@]2 (CC1) C) C) C) CC[C@H] (CO6) C
Molecular Formula
C44H70O16
Molecular Weight
855.03
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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