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Pipobroman

CAT: 0013-GTR19159043-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159043-01Size:200 mg
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Description
Pipobroman is an anti-cancer drug that probably acts as an alkylating agent. Pipobroman has well documented clinical activity in polycythemia vera (PV) and essential thrombocythemia (ET) . Pipobroman allows, within 3 months, to attain a response in more than 90% of patients, without clinically relevant toxicities. The 10-years risk of thrombosis of patients treated with Pipobroman is about 15%, The anti-proliferative activity of Pipobroman on bone marrow megakaryocytes seems of particular value in lowering the occurrence of post-PV and post-ET MMM, whose risk is the lowest registered with available treatments. The 10-year risk of acute leukemia with Pipobroman is 5% in PVand 3% in ET, which is only slightly higher than that expected as a natural evolution of the disease. In conclusion, the use of Pipobroman is a definite alternative to hydroxyurea in patients with PV and ET at high risk of thrombosis.
CAS Number
54-91-1
Product Name Alternative
NSC25154 | Pipobroman
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 36 mg/mL; 101.11 mM
Smiles
BrCCC (=O) N1CCN (CC1) C (=O) CCBr
Molecular Formula
C10H16Br2N2O2
Molecular Weight
356.06
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1,1'- (piperazine-1,4-diyl) bis (3-bromopropan-1-one)

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