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L189

CAT: 0013-GTR19158668-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19158668-01Size:200 mg
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Description
L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ) . L189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. L189 will not only provide insights into the cellular function of these enzymes but also serve as lead compounds for the development of anticancer agents.
CAS Number
64232-83-3
Product Name Alternative
L189 | L 189 | L-189
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 33 mg/mL; 33.99 mM
Smiles
Nc1[nH]c (=S) [nH]c (=O) c1\N=C\c1ccccc1
Molecular Formula
C11H10N4OS
Molecular Weight
246.29
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(E) -6-amino-5- (benzylideneamino) -2-thioxo-2,3-dihydropyrimidin-4 (1H) -one

Chemical Information

(E)-6-amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
CAS Number64232-83-3
PubChem CID824710
IUPAC Name6-amino-5-(benzylideneamino)-2-sulfanylidene-1H-pyrimidin-4-one
Molecular FormulaC11H10N4OS
Molecular Weight246.29
XLogP0.7
Topological Polar Surface Area112
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count17
Formal Charge0
Complexity396
SMILES
C1=CC=C(C=C1)C=NC2=C(NC(=S)NC2=O)N
InChI
InChI=1S/C11H10N4OS/c12-9-8(10(16)15-11(17)14-9)13-6-7-4-2-1-3-5-7/h1-6H,(H4,12,14,15,16,17)
InChIKey
SAKOXVNKDMWWLF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of (E)-6-amino-5-(benzylideneamino)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
CAS: 64232-83-3
CID: 824710
Formula: C11H10N4OS
MW: 246.29
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight246.29
XLogP30.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass246.05753213
Monoisotopic Mass246.05753213
Topological Polar Surface Area112 Ų
Heavy Atom Count17
Formal Charge0
Complexity396
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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