Products for Research Use Only

L189

CAT: 0013-GTR19158668-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19158668-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
L189 is a DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding. L189 inhibits base excision repair (BER) and non-homologous end joining (NHEJ) . L189 specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. L189 will not only provide insights into the cellular function of these enzymes but also serve as lead compounds for the development of anticancer agents.
CAS Number
64232-83-3
Product Name Alternative
L189 | L 189 | L-189
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 33 mg/mL; 33.99 mM
Smiles
Nc1[nH]c (=S) [nH]c (=O) c1\N=C\c1ccccc1
Molecular Formula
C11H10N4OS
Molecular Weight
246.29
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(E) -6-amino-5- (benzylideneamino) -2-thioxo-2,3-dihydropyrimidin-4 (1H) -one

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