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Punicalagin

CAT: 0013-GTR19159090-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159090-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects. It has been shown to prevent high-fat diet-induced obesity-associated accumulation of cardiac triglyceride and cholesterol, as well as myocardial damage, via AMPK-mediated modulation of mitochondria and phase II enzymes. (In Vitro) :Punicalagin (100 mg/ml) induces apoptosis in HT-29, HCT116 colon cells.Punicalagin slightly inhibits the PLpro activity with an IC50 of over 50 μM. Punicalagin inhibits the plaque formation of SARS-CoV-2 in a dose-dependent manner, with EC50 values of 7.20 μM.Punicalagin binds at an allosteric site in the dimer interface. Punicalagin inhibit SARS-CoV-2 replication by a mechanism other than preventing S-mediated viral entry. (In Vivo) :Punicalagin (10 mg/kg) inhibits the edema rate of 58.15% in rats.
CAS Number
65995-63-3
Purity
>98% (HPLC)
Solubility
In Vitro: H2O : 100 mg/mL (92.19 mM)
Smiles
Oc1c (O) c8c3c2c4c (C (=O) Oc12) c (c (O) c (O) c4OC3=O) c5c (O) c (O) c (O) cc5C (=O) OC[C@H]%10OC (O) [C@@H]%11OC (=O) c6cc (O) c (O) c (O) c6c7c (O) c (O) c (O) cc7C (=O) O[C@H]%11[C@@H]%10OC (=O) c9cc (O) c (O) c (O) c89
Molecular Formula
C48H28O30
Molecular Weight
1084.7
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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