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Salvianolic acid A

CAT: 0013-GTR19158436-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19158436-01Size:200 mg
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Description
Salvianolic acid A could protect the blood brain barrier through matrix metallopeptidase 9 (MMP-9) inhibition and anti-inflammation. (In Vivo) :A significant beneficial effect of Salvianolic acid A (SAA) is observed in the Salvianolic acid A treatment groups. Salvianolic acid A (20 mg/kg) could significantly prolonged the retention time of rats on the plate. While compared with sham operation group, the brain water content in model group significantly increases, which is attenuated significantly by Salvianolic acid A (10 and 20 mg/kg) . Compared with the model group, Salvianolic acid A (5, 10, and 20 mg/kg) could maintain the normal structures of neurons and increase neurons number. It is also found that Salvianolic acid A (20 mg/kg) could significantly reduce I/R induced MMP-9 upregulation. While the MMP-2 expression is not significantly affected by Salvianolic acid A. Tissue inhibitors of metalloproteinases (TIMPs) could inhibit the activity of MMPs through high affinity binding to MMPs catalytic domain.
CAS Number
96574-01-5
Product Name Alternative
Dan Phenolic Acid A
Purity
>98% (HPLC)
Solubility
DMSO:130 mg/mL; Ethanol:10 mg/mL
Smiles
OC (=O) [C@@H] (Cc1ccc (O) c (O) c1) OC (=O) \C=C\c1ccc (O) c (O) c1\C=C\c1ccc (O) c (O) c1
Molecular Formula
C26H22O10
Molecular Weight
494.45
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Salvianolic acid

Salvianolic acid A is a stilbenoid.

CAS Number96574-01-5
PubChem CID5281793
IUPAC Name(2R)-3-(3,4-dihydroxyphenyl)-2-[(E)-3-[2-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-3,4-dihydroxyphenyl]prop-2-enoyl]oxypropanoic acid
Molecular FormulaC26H22O10
Molecular Weight494.4
XLogP3.9
Topological Polar Surface Area185
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Heavy Atom Count36
Formal Charge0
Complexity798
SMILES
C1=CC(=C(C=C1C[C@H](C(=O)O)OC(=O)/C=C/C2=C(C(=C(C=C2)O)O)/C=C/C3=CC(=C(C=C3)O)O)O)O
InChI
InChI=1S/C26H22O10/c27-18-7-2-14(11-21(18)30)1-6-17-16(4-9-20(29)25(17)33)5-10-24(32)36-23(26(34)35)13-15-3-8-19(28)22(31)12-15/h1-12,23,27-31,33H,13H2,(H,34,35)/b6-1+,10-5+/t23-/m1/s1
InChIKey
YMGFTDKNIWPMGF-UCPJVGPRSA-N
Chemical Structure
2D Structure
2D structure of Salvianolic acid
CAS: 96574-01-5
CID: 5281793
Formula: C26H22O10
MW: 494.4
Interactive 3D Structure
Loading 3D structure...
Computed Properties
PropertyValue
Molecular Weight494.4
XLogP33.9
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Exact Mass494.12129689
Monoisotopic Mass494.12129689
Topological Polar Surface Area185 Ų
Heavy Atom Count36
Formal Charge0
Complexity798
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes