T-26c

CAT: 0013-GTR19158240-01Size: 200 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19158240-01Size:200 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor (IC50: 6.75 pM) . (In Vitro) :T-26c significantly inhibits the breakdown of collagen (87.4% inhibition at 0.1 μM) in IL-1β and oncostatin M stimulated cartilage. (In Vivo) :T-26c is well absorbed in all species at the oral dose of 10–20 mg/kg. Oral administration of the disodium salt formulations of T-26c to guinea pigs results in significant increases in AUC (8357 ng h/mL) and Cmax (1445 ng/ mL) compared with those of the free acid T-26c (AUC = 6478 ng h/ mL and Cmax= 911 ng/mL) .

CAS Number

869296-13-9

Purity

>98% (HPLC)

Solubility

DMSO: 12 mg/mL (25.03 mM) ; Water: Insoluble

Smiles

COc1cccc (CNC (=O) c2nc3scc (COCc4ccc (cc4) C (O) =O) c3c (=O) [nH]2) c1

Molecular Formula

C24H21N3O6S

Molecular Weight

479.51

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

4- (((2- ((3-methoxybenzyl) carbamoyl) -4-oxo-34-dihydrothieno[23-d]pyrimidin-5-yl) methoxy) methyl) benzoic acid

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Alternative Products

Catalog	Name
BA8022-50	T-26c
HY-100518A	T 26c (sodium)
A12853-25	T-26c 25mg
A12853-10	T-26c 10mg
A12853-1	T-26c 1mg
BT163666	T 26c disodium
A12853-50	T-26c 50mg
574927	T-26c disodium
A12853-100	T-26c 100mg
HY-100518R	T-26c (Standard)

T-26c

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