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Fosphenytoin sodium

CAT: 0013-GTR19158053-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19158053-01Size:1 g
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Description
Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin a voltage-gated sodium channel blocker. (In Vivo) :Fosphenytoin is an effective neuroprotectant against ischemia-induced damage. In fosphenytoin (30 mg/kg, i.m.) -treated rat 5 min after ischemia episode, hippocampal CA1 pyramidal neurons remain at near control level (13.90 +/- 0.92), however, GFAP staining iss not significantly changed. In fosphenytoin (84 mg/kg) -treated rat, the relative bioavailability of fosphenytoin is 83%. In fully kindled female Wistar rats, fosphenytoin dose-dependently increases the focal seizure (afterdischarge) threshold. Seizure severity and duration at threshold are reduced only after the highest does of fosphenytoin tested (84 mg/kg) .
CAS Number
92134-98-0
Product Name Alternative
ACC-9653
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
H2O:100 mg/mL (246.16 mM)
Smiles
[Na+].[Na+].[O-]P ([O-]) (=O) OCN1C (=O) NC (C1=O) (c1ccccc1) c1ccccc1
Molecular Formula
C16H13N2Na2O6P
Molecular Weight
406.24
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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