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CCT018159

CAT: 0013-GTR19157965-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157965-01Size:200 mg
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Description
The heat shock protein 90 (Hsp90) is a molecular chaperone that activates and maintains the biological functioning of several client proteins, many of which are associated with oncogenic signaling pathways. Its activity is driven by ATP and regulated by co-chaperones such as Hsp72. CCT018159 is a 3,4-diaryl pyrazoloresorcinol compound that inhibits the ATPase activity of Hsp90 with IC50 values of 3.2 and 6.6 μM for human Hsp90β and yeast Hsp90, respectively.At concentrations up to 100 μM, CCT018159 does not inhibit human Hsp72 ATPase or topoisomerase II, yet at 50 μM CCT018159 inhibits 13 out of a panel of 20 commonly studied kinases.
CAS Number
171009-07-7
Purity
>98% (HPLC)
Solubility
DMSO: 30 mg/ml
Smiles
CCc1cc (c (O) cc1O) c1n[nH]c (C) c1c1ccc2OCCOc2c1
Molecular Formula
C20H20N2O4
Molecular Weight
352.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-[4- (2,3-dihydo-1,4-benzodioxin-6-yl) -5-methyl-1H-pyrazol-3-yl]-6-ethyl-1,3-benzenediol

Alternative Products

CatalogName
MBS5802284CCT018159
WGA00907-01HSP90 Inhibitor, CCT018159

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