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THIQ

CAT: 0013-GTR19157922-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157922-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
THIQ is a selective melanocortin-4 receptor (MC4R) agonist (hMC4R and rMC4R with IC50 of 1.2 nM and 0.6 nM , respectively) . THIQ, a small molecule agonist of the MC4R, on the cell surface expression and signaling of ten intracellularly retained MC4R mutants using different cell lines. THIQ increased the cell surface expression of three mutants (N62S, C84R, and C271Y) and two of them (N62S and C84R) had increased signaling in HEK293 cells.THIQ increased the signaling of two other mutants (P78L and P260Q) without increasing their cell surface expression in HEK293 cells. In neuronal cells, THIQ exhibited a more potent effect, correcting the cell surface expression and signaling of seven mutants (N62S, I69R, P78L, C84R, W174C, P260Q, and C271Y) .
CAS Number
312637-48-2
Purity
>98% (HPLC)
Solubility
DMSO:245 mg/ml (415.84 mM; Need ultrasonic)
Smiles
Clc1ccc (C[C@@H] (NC (=O) [C@H]2Cc3ccccc3CN2) C (=O) N2CCC (Cn3cncn3) (CC2) C2CCCCC2) cc1
Molecular Formula
C33H41ClN6O2
Molecular Weight
589.17
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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