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Mifobate

CAT: 0013-GTR19157892-05Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157892-05Size:10 mg
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Description
Mifobate is a potent and specific antagonist of PPARγ. Mifobate shows antiobesity, antidiabetic and antiatherosclerotic effects[1].SR-202 is a new synthetic PPARgamma antagonist, which inhibits both TZD-stimulated recruitment of the coactivator steroid receptor coactivator-1 and TZD-induced transcriptional activity of the receptor. In cell culture, SR-202 efficiently antagonizes hormone- and TZD-induced adipocyte differentiation[1].In vivo, decreasing PPARgamma activity, either by treatment with SR-202 or by invalidation of one allele of the PPARgamma gene, leads to a reduction of both high fat diet-induced adipocyte hypertrophy and insulin resistance. These effects are accompanied by a smaller size of the adipocytes and a reduction of TNFalpha and leptin secretion. Treatment with SR-202 also dramatically improves insulin sensitivity in the diabetic ob/ob mice.
CAS Number
76541-72-5
Product Name Alternative
SR-202
Purity
>98% (HPLC)
Solubility
H2O:35.87 mg/mL (100.01 mM; Need ultrasonic and warming)
Smiles
COP (=O) (OC) OC (C1=CC=C (Cl) C=C1) P (=O) (OC) OC
Molecular Formula
C11H17ClO7P2
Molecular Weight
358.65
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Mifobate

Phosphoric acid [(4-chlorophenyl)-dimethoxyphosphorylmethyl] dimethyl ester is a trialkyl phosphate.

CAS Number76541-72-5
PubChem CID60910
IUPAC Name[(4-chlorophenyl)-dimethoxyphosphorylmethyl] dimethyl phosphate
Molecular FormulaC11H17ClO7P2
Molecular Weight358.65
XLogP1
Topological Polar Surface Area80.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Heavy Atom Count21
Formal Charge0
Complexity395
SMILES
COP(=O)(C(C1=CC=C(C=C1)Cl)OP(=O)(OC)OC)OC
InChI
InChI=1S/C11H17ClO7P2/c1-15-20(13,16-2)11(19-21(14,17-3)18-4)9-5-7-10(12)8-6-9/h5-8,11H,1-4H3
InChIKey
VQHUQHAPWMNBLP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Mifobate
CAS: 76541-72-5
CID: 60910
Formula: C11H17ClO7P2
MW: 358.65
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight358.65
XLogP31
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count8
Exact Mass358.0138046
Monoisotopic Mass358.0138046
Topological Polar Surface Area80.3 Ų
Heavy Atom Count21
Formal Charge0
Complexity395
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5755186Mifobate
HY-100277RMifobate (Standard)

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