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Mifobate

CAT: 0013-GTR19157892-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157892-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mifobate is a potent and specific antagonist of PPARγ. Mifobate shows antiobesity, antidiabetic and antiatherosclerotic effects[1].SR-202 is a new synthetic PPARgamma antagonist, which inhibits both TZD-stimulated recruitment of the coactivator steroid receptor coactivator-1 and TZD-induced transcriptional activity of the receptor. In cell culture, SR-202 efficiently antagonizes hormone- and TZD-induced adipocyte differentiation[1].In vivo, decreasing PPARgamma activity, either by treatment with SR-202 or by invalidation of one allele of the PPARgamma gene, leads to a reduction of both high fat diet-induced adipocyte hypertrophy and insulin resistance. These effects are accompanied by a smaller size of the adipocytes and a reduction of TNFalpha and leptin secretion. Treatment with SR-202 also dramatically improves insulin sensitivity in the diabetic ob/ob mice.
CAS Number
76541-72-5
Product Name Alternative
SR-202
Purity
>98% (HPLC)
Solubility
H2O:35.87 mg/mL (100.01 mM; Need ultrasonic and warming)
Smiles
COP (=O) (OC) OC (C1=CC=C (Cl) C=C1) P (=O) (OC) OC
Molecular Formula
C11H17ClO7P2
Molecular Weight
358.65
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Alternative Products

CatalogName
C07311Mifobate
HY-100277RMifobate (Standard)

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