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NCGC00244536

CAT: 0013-GTR19157848-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157848-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NCGC00244536 is a potent KDM4B inhibitor (IC50: 10 nM) .NCGC00244536 effectively inhibits AR-positive cell lines, including LNCaP and VCaP, with IC50s in the sub-micromolar range, and abolishes androgen-stimulated LNCaP cell growth. NCGC00244536 displays high selectivity for the fast-growing AR-negative PC3 cells (IC50: 40 nM) and over 100-fold selectivity against the immortalized prostate epithelial cell lines PrEC1 and PrEC4. NCGC00244536 is also potent in inhibiting the growth of other cancer cell lines, including the breast cancer cell lines MDA-MB2 and MCF-7, with micromolar IC50s.Treatment with NCGC00244536 results in significant inhibition of tumor growth and animals do not exhibit any major toxicity and appear to be normal. NCGC00244536-treated tumors have a significant amount of cell apoptosis, necrosis, and fibrosis.
CAS Number
2003260-55-5
Product Name Alternative
KDM4B Inhibitor B3
Purity
>98% (HPLC)
Solubility
DMSO:100 mg/mL (261.47 mM)
Smiles
OC1=C2N=CC=CC2=CC (=C1) C1=CC (=CC=C1) C (=O) NCCCC1=CC=CC=C1
Molecular Formula
C25H22N2O2
Molecular Weight
382.45
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Alternative Products

CatalogName
BA4782-25NCGC00244536
A13025-50NCGC00244536 50mg
A13025-25NCGC00244536 25mg
A13025-1NCGC00244536 1mg
A13025-100NCGC00244536 100mg
A13025-10NCGC00244536 10mg
A13025-5NCGC00244536 5mg
A13025-10mM-DNCGC00244536 10mM * 1mL in DMSO

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