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FPTQ

CAT: 0013-GTR19157828-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157828-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FPTQ is an antagonist of mGluR1.FPTQ is a synthetic isoquinoline derivative.Neutrophils translocation in the zebrafish tail-transected model was inhibited by FPTQ. Neutrophil aggregation was also inhibited by FPTQ in the LPS-stimulated zebrafish model. Decreased mRNA expression of the pro-inflammatory cytokine genes, interleukin-1β (il-1β) and interleukin-6 (il-6), was found in zebrafish larvae injected with FPTQ. Additionally, production of nitric oxide was inhibited by FPTQ in RAW264.7 macrophage cells treated with LPS. Moreover, the mRNA expression of Il-1β and Il-6 suppressed by FPTQ treatment in RAW264.7 macrophage cells, and an enzyme immunoassay showed that FPTQ suppressed the secretion of IL-1β and IL-6 in RAW264.7 cells. These results demonstrate that FPTQ reduced inflammatory responses and, therefore, suggest that it may be effective as an anti-inflammatory agent.
CAS Number
1025802-62-3
Purity
>98% (HPLC)
Smiles
Cc1c (nnn1-c1cccnc1F) -c1ccc2cccnc2c1
Molecular Formula
C17H12FN5
Molecular Weight
305.32
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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