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RABBIT ANTI HRK

CAT: 0544-MBS223071-01Size: 0.05 mgDry Ice: NoHazardous: No
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CAT#:0544-MBS223071-01Size:0.05 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
9007-83-4
Gene Name
[HRK]
NCBI Gene ID
8739
Storage Conditions
Store at 4 °C or at -20 °C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Specificity
This item detects Harakiri (HRK), also known as DP5. HRK is a BH3 only protein of the Bcl-2 family, which promotes Bax dependent apoptosis. HRK regulates apoptosis through its interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL, and in conjunction to the mitochondrial pore forming protein p32. HRK is thought to have a specific role in initiating neuronal and haematopoietic cell apoptosis, in particular to growth factor deprivation.
Aberrant methylation of HRK is frequently detected in primary colorectal cancers. Despite its predicted molecular weight, HRK often migrates at 12-15kD.
Other Gene Names
[HRK; HRK; DP5; HARAKIRI; BID3]
Short Name
[HRK]
Other Product Names
[activator of apoptosis harakiri; Activator of apoptosis harakiri; activator of apoptosis harakiri; BCL2-interacting protein; BH3-interacting domain-containing protein 3; activator of apoptosis Hrk; death protein 5; harakiri, BCL2 interacting protein (contains only BH3 domain); neuronal death protein DP5; harakiri, BCL2 interacting protein; BH3-interacting domain-containing protein 3; Neuronal death protein DP5]
NCBI GI Number
4504493
NCBI Accession Number
NP_003797.1
NCBI GB Accession Number
NM_003806.2
Uniprot Accession Number
O00198

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