Products for Research Use Only
RegisterLogin

Raphin1 acetate

CAT: 0013-GTR19157822-03Size: 1 gDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19157822-03Size:1 g
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Raphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor.Raphin1, a selective inhibitor of R15B. In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis. In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitment.Raphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease.
CAS Number
2242616-04-0
Purity
>98% (HPLC)
Solubility
DMSO:40 mg/mL (137.4 mM; Need ultrasonic)
Smiles
CC (O) =O.NC (=N) N\N=C\c1cccc (Cl) c1Cl
Molecular Formula
C10H12Cl2N4O2
Molecular Weight
291.13
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Raphin1 acetate
CAS Number2242616-04-0
PubChem CID139035044
IUPAC Nameacetic acid;2-[(E)-(2,3-dichlorophenyl)methylideneamino]guanidine
Molecular FormulaC10H12Cl2N4O2
Molecular Weight291.13
Topological Polar Surface Area114
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count18
Formal Charge0
Complexity269
SMILES
CC(=O)O.C1=CC(=C(C(=C1)Cl)Cl)/C=N/N=C(N)N
InChI
InChI=1S/C8H8Cl2N4.C2H4O2/c9-6-3-1-2-5(7(6)10)4-13-14-8(11)12;1-2(3)4/h1-4H,(H4,11,12,14);1H3,(H,3,4)/b13-4+;
InChIKey
WSDLUFBVKWLRSN-GAYQJXMFSA-N
Chemical Structure
2D Structure
2D structure of Raphin1 acetate
CAS: 2242616-04-0
CID: 139035044
Formula: C10H12Cl2N4O2
MW: 291.13
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight291.13
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass290.0337310
Monoisotopic Mass290.0337310
Topological Polar Surface Area114 Ų
Heavy Atom Count18
Formal Charge0
Complexity269
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19167370-01Raphin1
GTR19222139-01Methyl acetate-PEG1-methyl acetate
GTR19175729-01Taltirelin acetate
GTR19277740-01(±) -Sabinyl acetate
GTR19203231-01Crizotinib acetate
GTR19248688-01Pentadecyl acetate
GTR19245390-01Tetramethylammonium acetate
GTR19243996-01Norethindrone acetate
GTR19243541-01Dodecyl acetate
GTR19242893-01Daucosterin acetate

Alternative Products

CatalogName
MBS3612008-01Raphin1 acetate
HY-123960A-01Raphin1 (acetate)
A21373-100Raphin1 acetate 100mg
A21373-10Raphin1 acetate 10mg
A21373-5Raphin1 acetate 5mg
A21373-200Raphin1 acetate 200mg
A21373-50Raphin1 acetate 50mg
A21373-25Raphin1 acetate 25mg
A21373-10mM-DRaphin1 acetate 10mM * 1mL in DMSO
BA8148-25Raphin1

Popular Products