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Raphin1 acetate

CAT: 0013-GTR19157822-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157822-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Raphin1 acetate is a selective and orally bioavailable regulatory phosphatase PPP1R15B (R15B) inhibitor.Raphin1, a selective inhibitor of R15B. In cells, Raphin1 caused a rapid and transient accumulation of its phosphorylated substrate, resulting in a transient attenuation of protein synthesis. In vitro, Raphin1 inhibits the recombinant R15B-PP1c holoenzyme, but not the closely related R15A-PP1c, by interfering with substrate recruitment.Raphin1 was orally bioavailable, crossed the blood-brain barrier, and demonstrated efficacy in a mouse model of Huntington's disease.
CAS Number
2242616-04-0
Purity
>98% (HPLC)
Solubility
DMSO:40 mg/mL (137.4 mM; Need ultrasonic)
Smiles
CC (O) =O.NC (=N) N\N=C\c1cccc (Cl) c1Cl
Molecular Formula
C10H12Cl2N4O2
Molecular Weight
291.13
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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