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M-3M3FBS

CAT: 0013-GTR19157814-06Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157814-06Size:25 mg
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Description
M-3M3FBS is a phospholipase C (PLC) activator. m-3M3FBS stimulated a transient intracellular calcium concentration ([Ca (2+) ] (i) ) increase in neutrophils. Moreover, m-3M3FBS stimulated the formation of inositol phosphates in U937 cells, indicating that it stimulates PLC activity. The compound showed no cell-type specificity in terms of [Ca (2+) ] (i) increase in the various cell lines including leukocytes, fibroblasts, and neuronal cells, also ruled out the possible involvement of heterotrimeric G proteins in m-3M3FBS-stimulated signaling by confirming the following: 1) pertussis toxin does not inhibit m-3M3FBS-induced [Ca (2+) ] (i) increase; 2) m-3M3FBS does not stimulate cyclic AMP generation; and 3) the inhibition of G (q) by the regulator of G protein-signaling 2 does not affect the m-3M3FBS-induced [Ca (2+) ] (i) increase. m-3M3FBS stimulated PLC activity in vitro. The purified isoforms of PLC that were tested (i.e., beta2, beta3, gamma1, gamma2, and delta1) were activated by m-3M3FBS and showed no isoform specificity.
CAS Number
200933-14-8
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (291.24 mM)
Smiles
Cc1cc (C) c (c (C) c1) S (=O) (=O) Nc1cccc (c1) C (F) (F) F
Molecular Formula
C16H16F3NO2S
Molecular Weight
343.36
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

m-3M3FBS

2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide is a sulfonamide.

CAS Number200933-14-8
PubChem CID761523
IUPAC Name2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide
Molecular FormulaC16H16F3NO2S
Molecular Weight343.4
XLogP4.4
Topological Polar Surface Area54.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count23
Formal Charge0
Complexity488
SMILES
CC1=CC(=C(C(=C1)C)S(=O)(=O)NC2=CC=CC(=C2)C(F)(F)F)C
InChI
InChI=1S/C16H16F3NO2S/c1-10-7-11(2)15(12(3)8-10)23(21,22)20-14-6-4-5-13(9-14)16(17,18)19/h4-9,20H,1-3H3
InChIKey
ZIIUUSVHCHPIQD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of m-3M3FBS
CAS: 200933-14-8
CID: 761523
Formula: C16H16F3NO2S
MW: 343.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight343.4
XLogP34.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass343.08538441
Monoisotopic Mass343.08538441
Topological Polar Surface Area54.6 Ų
Heavy Atom Count23
Formal Charge0
Complexity488
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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