Products for Research Use Only
RegisterLogin

H-151

CAT: 0013-GTR19157555-04Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19157555-04Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
H-151 is a highly potent selective and covalent antagonist of STING reduces TBK1 phosphorylation and suppresses human STING palmitoylation. (In Vitro) :H-151 (0.02-2 μM) reduces IFNβ luciferase reporter measurements of HEK293T cells.H-151 (0.5 μM; 2 h) inhibits the phosphorylation of TBK1 in THP-1 cells.H-151 (1 μM; 3 h) suppresses hsSTING palmitoylation. (In Vivo) :H-151 (750 nmol per mouse; a single i.p.) markedly reduces systemic cytokine responses in CMA-treated mice.H-151 (750 nmol per mouse; i.p. daily for 7 d) exhibits notable efficacy in Trex1 / mice that expressed a bioluminescent IFNβ reporter.H-151 (750 nmol per mouse; i.p.) reaches effective systemic levels, displays a short half-life in the serum and forms an adduct to mmSTING in wild-type mice.
CAS Number
941987-60-6
Purity
>98% (HPLC)
Solubility
DMSO:125 mg/mL (447.48 mM; Need ultrasonic)
Smiles
CCc1ccc (NC (=O) Nc2c[nH]c3ccccc23) cc1
Molecular Formula
C17H17N3O?
Molecular Weight
279.34
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (4-Ethylphenyl) -N'-1H-indol-3-yl-urea

Chemical Information

1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea

H-151 is an inhibitor of the stimulator of interferon genes (STING) protein.

CAS Number941987-60-6
PubChem CID7616033
IUPAC Name1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
Molecular FormulaC17H17N3O
Molecular Weight279.34
XLogP3.4
Topological Polar Surface Area56.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count1
Rotatable Bond Count3
Heavy Atom Count21
Formal Charge0
Complexity352
SMILES
CCC1=CC=C(C=C1)NC(=O)NC2=CNC3=CC=CC=C32
InChI
InChI=1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21)
InChIKey
UJZDIKVQFMCLBE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea
CAS: 941987-60-6
CID: 7616033
Formula: C17H17N3O
MW: 279.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight279.34
XLogP33.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count1
Rotatable Bond Count3
Exact Mass279.137162174
Monoisotopic Mass279.137162174
Topological Polar Surface Area56.9 Ų
Heavy Atom Count21
Formal Charge0
Complexity352
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19258769-01EGFR-IN-151
GTR19297819-01RBM1-151
GTR19235070-01JTE-151
GTR19168775-01Anticancer agent 151
GTR19262444-01Antitumor agent-151
GTR17999944CAB-151 Antibody
GTR19301251-01Pigment yellow 151
GTR19029721-01PLP (139-151)
GTR17966219Tag-151 Antibody
GTR19338992-01Disperse red 151

Alternative Products

CatalogName
inh-h151-5H-151
584647H 151

Popular Products