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TAK-960

CAT: 0013-GTR19157392-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157392-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TAK-960 is an orally bioavailable selective inhibitor of Plks with IC50 values of 0.8 16.9 and 50.2 nM for Plk1 Plk2 and Plk3 respectively. (In Vitro) :TAK-960 treatment causes accumulation of G2-M cells, aberrant polo mitosis morphology, and increased phosphorylation of histone H3 (pHH3) . TAK-960 (2-1000 nM; 72 hours) inhibits proliferation of multiple cancer cell lines, with mean EC50 values ranging from 8.4 to 46.9 nM, but not in nondividing normal cells.TAK-960 (8 nM) leads to G2/M cell cycle arrest without significant cytotoxicity in HeLa cells. (In Vivo) :TAK-960 exhibits (10 mg/kg; p.o.; once daily for 2 weeks) significant efficacy against multiple tumor xenografts.In animal models, TAK-960 (p.o.) increases pHH3 in a dose-dependent manner and significantly inhibits the growth of HT-29 colorectal cancer xenografts.
CAS Number
1137868-52-0
Field of Research
Epigenetics & Chromatin
Purity
>98% (HPLC)
Solubility
DMSO:35 mg/mL (62.32 mM)
Smiles
COc1cc (C (=O) NC2CCN (C) CC2) c (F) cc1Nc1ncc2N (C) C (=O) C (F) (F) CN (C3CCCC3) c2n1
Molecular Formula
C27H34F3N7O3
Molecular Weight
561.6
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4- ((9-cyclopentyl-77-difluoro-5-methyl-6-oxo-6789-tetrahydro-5H-pyrimido[45-b][14]diazepin-2-yl) amino) -2-fluoro-5-methoxy-N- (1-methylpiperidin-4-yl) benzamide

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Alternative Products

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S1239-5mgTAK-960
FT104283-01TAK 960
HY-15160CTAK-960 (monohydrochloride)
T72269TAK-960 dihydrochloride
HY-15160ATAK-960 (hydrochloride)
T64216-01TAK-960 hydrochloride
A11146-25TAK-960 25mg
A11146-10TAK-960 10mg
256801-01TAK 960 hydrochloride
A11146-100TAK-960 100mg

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