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TAK-243

CAT: 0013-GTR19174126-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19174126-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TAK-243 (MLN7243) is a potent and selective inhibitor of the ubiquitin-activating enzyme (UAE/UBA1) with an IC50 of 1 nM. It effectively blocks global protein ubiquitination, disrupting key cellular signaling pathways. This mechanism underlies its observed pro-apoptotic and antitumor effects in both in vitro and in vivo cancer research models.
CAS Number
1450833-55-2
Product Name Alternative
Apoptosis, E3Enzyme, E2 conjugating enzyme, E2 Enzyme, E2Enzyme, E3 Enzyme, E3 ligating enzyme, E1 activating enzyme, E1 Enzyme, E1/E2/E3 Enzyme, E1Enzyme, Inhibitor, inhibit, NF-κB, NFκB, NF-kB, NFkB, MLN 7243, MLN7243, MLN-7243, Nuclear factor-kappaB, Nuclear factor-κB, UBA1, Ubiquitin activating enzyme, Ubiquitin conjugating enzyme, Ubiquitin ligase, TAK 243, TAK243, TAK-243
Field of Research
Cell Biology, Epigenetics & Chromatin, Protein Biochemistry, Signal Transduction
Purity
98.09% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (9.62 mM) ; DMSO:237.5 mg/mL (457.15 mM)
Smiles
NS (=O) (=O) OC[C@H]1C[C@@H] (Nc2ccnc3cc (nn23) -c2cccc (SC (F) (F) F) c2) [C@H] (O) [C@@H]1O
Molecular Formula
C19H20F3N5O5S2
Molecular Weight
519.52
Storage Conditions
-20°C
Notes
For research use only.

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Alternative Products

CatalogName
BT165712-01TAK 243
HY-100487-01TAK-243
A20369-10TAK-243 10mg
A20369-5TAK-243 5mg
A20369-1TAK-243 1mg
C13356-01TAK-243 (MLN7243)
A20369-100TAK-243 100mg
A20369-50TAK-243 50mg
A20369-2TAK-243 2mg
HY-100487RTAK-243 (Standard)

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