Products for Research Use Only
RegisterLogin

LY2828360

CAT: 0013-GTR19157313-01Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19157313-01Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
LY2828360 is a cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM) . It selectively activates CB2 over CB1 in a GTPγS binding assay (EC50s = 20.1 and >100000 nM respectively) . (In Vivo) :In WT mice, acute systemic administration of LY2828360 suppresses paclitaxel-induced mechanical and cold allodynia in a dose-dependent manner. LY2828360 produces time-dependent suppressions of paclitaxel-evoked mechanical and cold hypersensitivities and suppression of allodynia is maintained for at least 4.5 h post-injection relative to drug pre-injection levels. At 24 h post-injection, paclitaxel-induced mechanical allodynia has returned to drug pre-injection levels of hypersensitivity. Residual suppression of cold allodynia was absent by 72 h post LY2828360 treatment. Previously chronic administration of LY2828360 blocks the development of tolerance to the antiallodynic effects of morphine in WT but not in CB2KO mice. Chronic LY2828360 treatment suppresses paclitaxel-induced mechanical and cold allodynia in WT mice but not in CB2KO mice previously render tolerant to morphine.
CAS Number
1231220-79-3
Purity
>98% (HPLC)
Solubility
DMSO:20.83 mg/mL (48.79 mM)
Smiles
CN1CCN (CC1) c1nc (C) nc2n (C3CCOCC3) c (nc12) -c1ccccc1Cl
Molecular Formula
C22H27ClN6O
Molecular Weight
426.94
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
8- (2-Chloro-phenyl) -2-methyl-6- (4-methyl-piperazin-1-yl) -9- (tetrahydro-pyran-4-yl) -9H-purine

Alternative Products

CatalogName
MBS3610694-01LY2828360
A22228-100LY2828360 100mg
A22228-5LY2828360 5mg
A22228-50LY2828360 50mg
A22228-10LY2828360 10mg
A22228-25LY2828360 25mg
A22228-2LY2828360 2mg

Popular Products