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RSV604

CAT: 0013-GTR19157265-02Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19157265-02Size:1 g
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Description
RSV-604 is an inhibitor of respiratory syncytial virus (RSV) that binds to RSV nucleoprotein (Kd = 1.31 μM) . (In Vitro) :RSV604 (5 days) inhibits the growth of four laboratory strains of RSV (RSS, Long, A2 and B), with EC50s ranging from 0.5 to 0.9 μM in plaque reduction assay.RSV604 (6 days) inhibits RSV-induced HEp-2 cell death, with an EC50 of 0.86 μM.RSV604 (3 days) reduces viral antigen synthesis in RSV-infected HEp-2 cells, with an EC50 of 1.7 μM.RSV604 (1-20 μM; 7 days) dose-dependently inhibits RSV infection in human airway epithelial (HAE) cells, with no gross cytotoxicity, leakage of basolateral fluid to the apical surface, or alteration of cilium beat frequency.
CAS Number
676128-63-5
Product Name Alternative
(S) -1- (2-Fluorophenyl) -3- (2-oxo-5-phenyl-23-dihydro-1H-benzo[e][14]diazepin-3-yl) urea
Purity
>98% (HPLC)
Solubility
DMSO:195 mg/mL (502.07 mM)
Smiles
Fc1ccccc1NC (=O) N[C@H]1N=C (c2ccccc2) c2ccccc2NC1=O
Molecular Formula
C22H17FN4O2
Molecular Weight
388.39
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(S) -1- (2-fluorophenyl) -3- (2-oxo-5-phenyl-23-dihydro-1H-benzo[e][14]diazepin-3-yl) urea

Chemical Information

1-(2-fluorophenyl)-3-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]urea

RSV-604 is under investigation in clinical trial NCT00416442 (Safety, Tolerability and Pharmacokinetic Study of Single and Multiple Intravenous Doses of RSV604 in Healthy Subjects.).

CAS Number676128-63-5
PubChem CID5279172
IUPAC Name1-(2-fluorophenyl)-3-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]urea
Molecular FormulaC22H17FN4O2
Molecular Weight388.4
XLogP3.3
Topological Polar Surface Area82.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count29
Formal Charge0
Complexity634
SMILES
C1=CC=C(C=C1)C2=N[C@@H](C(=O)NC3=CC=CC=C32)NC(=O)NC4=CC=CC=C4F
InChI
InChI=1S/C22H17FN4O2/c23-16-11-5-7-13-18(16)25-22(29)27-20-21(28)24-17-12-6-4-10-15(17)19(26-20)14-8-2-1-3-9-14/h1-13,20H,(H,24,28)(H2,25,27,29)/t20-/m1/s1
InChIKey
MTPVBMVUENFFLL-HXUWFJFHSA-N
Chemical Structure
2D Structure
2D structure of 1-(2-fluorophenyl)-3-[(3S)-2-oxo-5-phenyl-1,3-dihydro-1,4-benzodiazepin-3-yl]urea
CAS: 676128-63-5
CID: 5279172
Formula: C22H17FN4O2
MW: 388.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight388.4
XLogP33.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass388.13355396
Monoisotopic Mass388.13355396
Topological Polar Surface Area82.6 Ų
Heavy Atom Count29
Formal Charge0
Complexity634
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
M20757-01RSV604
BCB12862-01RSV604 racemate
A21355-50RSV604 50mg
A21355-200RSV604 200mg
A21355-5RSV604 5mg
A21355-2RSV604 2mg
A21355-100RSV604 100mg
A21355-10RSV604 10mg

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