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Tomatidine

CAT: 0013-GTR19157051-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19157051-01Size:100 mg
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Description
Tomatidine decreases inducible NO synthase and COX-2 expression through suppression of I-κBα phosphorylation, NF-κB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Tomatidine, solasodine and diosgenin (40 μM) show 66%, 22% and 41% inhibition of nitrite production, respectively. The iNOS protein is barely detectable in unstimulated cells but markedly increases after LPS treatment, and Tomatidine causes dose-dependent inhibition of LPS-induced iNOS expression. p65 is the major component of NF-κB in LPS-stimulated macrophages, the effect of Tomatidine on p65 DNA-binding activity is determined. In the presence of Tomatidine at 10-40 μM, the binding activity of NF-κB is suppressed in a dose-dependent manner. Tomatidine inhibits the phosphorylation of I-κB, blocks the I-κB production, and furthermore suppresses p65 NF-κB translocation to the nucleus and modulated binding activity.
CAS Number
77-59-8
Purity
>98% (HPLC)
Solubility
DMSO : 2.86 mg/mL (6.88 mM; Need ultrasonic) ; H2O : < 0.1 mg/mL (insoluble)
Smiles
[H][C@]1 (O[C@]2 (NC[C@@H] (C) CC2) [C@H]3C) C[C@@]4 ([H]) [C@]5 ([H]) CC[C@@]6 ([H]) C[C@@H] (O) CC[C@]6 (C) [C@@]5 ([H]) CC[C@]4 (C) [C@]13[H]
Molecular Formula
C??H??NO?
Molecular Weight
415.65
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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