Products for Research Use Only
RegisterLogin

7α,25-Dihydroxycholesterol

CAT: 0013-GTR19156934-01Size: 100 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19156934-01Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183) . 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells, and it is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM) . In vitro, 7α, 25-dihydroxycholesterol (7α,25-OHC) stimulates the migration of EBI2-expressing mouse B and T cells with half-maximum effective concentration values around 500 pM. but it had no effect on EBI2-deficient cells[1].EBI2-deficient B cells or normal B cells desensitized by 7α,25-Dihydroxycholesterol (1 μM; 1.5 hours) pre-treatment shows reduced homing to follicular areas of the spleen.
CAS Number
64907-22-8
Product Name Alternative
7α,25-OHC
Purity
>98% (HPLC)
Solubility
DMSO:1 mg/mL (2.39 mM; Need ultrasonic)
Smiles
[H][C@@]1 (CC[C@@]2 ([H]) [C@]3 ([H]) [C@H] (O) C=C4C[C@@H] (O) CC[C@]4 (C) [C@@]3 ([H]) CC[C@]12C) [C@H] (C) CCCC (C) (C) O
Molecular Formula
C27H46O3
Molecular Weight
418.65
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Related Products

CatalogName
GTR19239931-017α,24 (S) -Dihydroxycholesterol
GTR191839437,22,25-Stigmastatrienol
GTR19208186-01JW-7-25-1
GTR19063693-01BMV Gag- (7−25)
GTR19017355-0125-hydroxycholesterol 7-alpha-hydroxylase
GTR19017307-0125-hydroxycholesterol 7-alpha-hydroxylase
GTR19232187-017-keto-25-hydroxy Cholesterol
GTR19017397-0125-hydroxycholesterol 7-alpha-hydroxylase
GTR19261951-01Methylsolfonyl 25 (S) -Δ7-dafachronic acid
GTR19258168-015β-Cholestane-3α,7α,12α,25-tetrol

Alternative Products

CatalogName
M22488-017α,25-Dihydroxycholesterol
HY-N104937β,25-Dihydroxycholesterol
PCA90722-017±,25-Dihydroxycholesterol
HY-113962S-017α,25-Dihydroxycholesterol-d6
HY-4008977α,25-Dihydroxycholesterol intermediate-1
TRC-D229525-5MG(4Beta)-7-Dehydro-4,25-dihydroxycholesterol
MBS58174347beta,25-Dihydroxycholesterol
007781(4α) -7-Dehydro-4,25-dihydroxycholesterol
007779(4β) -7-Dehydro-4,25-dihydroxycholesterol
MBS6049816-01(4alpha)-7-Dehydro-4,25-dihydroxycholesterol

Popular Products