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TKIM

CAT: 0013-GTR19156884-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156884-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.TKIM binds to the pocket of the IM state of TREK-1, which differs from the binding of common inhibitors, which bind to channels in the inactive state. Overall, identified an allosteric ligand-binding site and a new mechanistic inhibitor for TREK-1, suggesting that IM states of ion channels may be promising druggable targets for use in discovering allosteric modulators.
CAS Number
326921-25-9
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 250 mg/mL (672.33 mM)
Smiles
Clc1ccc (cc1) C (=O) NNC (=O) CSc1ccc2ccccc2n1
Molecular Formula
C18H14ClN3O2S?
Molecular Weight
371.05
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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