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9-ING-41

CAT: 0013-GTR19156865-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156865-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
9-ING-41 is a glycogen synthase kinase-3 inhibitor.9-ING-41 (2, 4 μM; 48 hours) decreases neuroblastoma cell viability induces apoptosis. 9-ING-41 (0.1-1 μM) inhibits GSK-3 leading to a decreased expression of the NF-κB target XIAP and significant apoptosis in neuroblastoma cells as shown by PARP cleavage, an apoptosis marker. 9-ING-41 (0.5, 1.0, 1.5, 2.0 μM) inhibits the proliferation rate of all TCL and MCL lines with concentrations as low as 1.0 mM. 9-ING-41 (1, 2 μM; 24 hours) is a potent cell cycle-blocking agent for lymphoma cells[2].9-ING-41 (40 mg/kg/every other day; for 17 days) has single-agent antitumor activity in a mouse model of MCL.
CAS Number
1034895-42-5
Purity
>98% (HPLC)
Solubility
DMSO:97 mg/mL (239.89mM; Need ultrasonic)
Smiles
Cn1cc (C2=C (C (=O) NC2=O) c2coc3ccc (F) cc23) c2cc3OCOc3cc12
Molecular Formula
C22H13FN2O5
Molecular Weight
404.35
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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