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BAM 15

CAT: 0013-GTR19156861-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19156861-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAM 15 is an uncoupler of mitochondrial protonophore. BAM 15 is fully capable of increasing mitochondrial respiration in the presence of oligomycin and does so across a broader concentration range than FCCP in both myoblasts and hepatocytes and it is able to increase O2 consumption across a broad dosing range without increasing ROS. BAM 15 and FCCP are structurally unrelated. Which is observed that low doses of BAM 15 from 100 nM to 1 μM increase cellular O2 consumption rate (OCR) to a similar degree as FCCP, However higher concentrations from 1 μM to 50 μM reveal that BAM 15 is able to maintain uncoupled respiration at a high rate in a range of cell lines. BAM 15 induces mitochondrial swelling, demonstrating that BAM 15 is a protonophore. BAM15-treated cells are more viable than FCCP-treated cells when administered across a broad dosing range up to 50 μM.Compare to vehicle-treated mice, animals that receive BAM 15 are protected from kidney injury as indicated by lower plasma creatinine levels at 24 and 48 h post-ischemia, reduced tubular necrosis, less obstruction of proximal tubules, less depletion of brush border villi, and less immune cell infiltration.
CAS Number
210302-17-3
Purity
>98% (HPLC)
Solubility
DMSO:72 mg/mL (211.58mM; Need ultrasonic)
Smiles
Fc1ccccc1Nc1nc2nonc2nc1Nc1ccccc1F
Molecular Formula
C16H10F2N6O
Molecular Weight
340.29
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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