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TK216

CAT: 0013-GTR19156744-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156744-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TK216 is a potent inhibitor of E26 transformation-specific (ETS) with anticancer activity.In DLBCL cell lines, TK216 (500 nM; for 24-72 hours) induces apoptosis. TK216 (0.03, 0.06, 0.125, 0.25, 0.5 μM) results in a dose-dependent inhibition of proliferation in Ewing Sarcoma A4573 cell line. In DLBCL cell lines, TK216 (0.1, 0.3, 1 μM) induces apoptosis, with the amount of cleaved-Caspase 3 normalized to b-actin and presented as fold over control. TK216 has IC50s of 0.363 μM and 0.152 μM for the HL-60 AML cell line and TMD-8 DLBCL cell line. TK216 inhibits EWS-FLI1 (Ewing sarcoma breakpoint region 1/Friend leukemia virus integration 1 fusion protein) protein interactions, leading to a decrease in transcription and proliferation.In the TMD-8 xenograft model, TK216 (po; 100 mg/kg; twice daily for 13 days) results in tumor growth inhibition.
CAS Number
1903783-48-1
Purity
>98% (HPLC)
Solubility
DMSO:249 mg/mL (661.83 mM)
Smiles
OC1 (CC (=O) c2ccc (cc2) C2CC2) C (=O) Nc2c1c (Cl) ccc2Cl
Molecular Formula
C19H15Cl2NO3
Molecular Weight
376.23
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Alternative Products

CatalogName
BA3968-5.1TK216
HY-122903A-01(-) -TK216
T39329-01(+)-TK216
HY-122903B-01(+) -TK216
T39330-01(-)-TK216
HY-122903S-01TK216-d4

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