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GW-870086

CAT: 0013-GTR19156741-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156741-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GW-870086 is an effective anti-inflammatory agent. GW-870086 also plays a role in a glucocorticoid receptor agonist (pIC50: 10.1 in A549 cells expressing NF-κB) . GW-870086 (10-100 nM) obviously increases fibronectin secretion. GW-870086 (1 pM-1 μM) dose-dependently inhibits the L-6 release induced by TNF-α in A549 epithelial carcinoma cells and by IL-1 in MG63 osteosarcoma cells (pIC50s, 9.6, 10.2) . GW-870086 displays no effect on the MMTV reporter genes in A549 cells and has little or no activity at the oestrogen receptor, progesterone receptor, progesterone receptor, mineralocorticoid receptor, or androgen receptor. GW-870086 also has no effect on MMP2 secretion and does not enhance cellular myocilin.
CAS Number
827319-43-7
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (178.69 mM)
Smiles
[H][C@@]12C[C@@H] (C) [C@] (OC (=O) C3C (C) (C) C3 (C) C) (C (=O) OCC#N) [C@@]1 (C) C[C@H] (O) [C@@]1 (F) [C@@]2 ([H]) C[C@H] (F) C2=CC (=O) C=C[C@]12C
Molecular Formula
C31H39F2NO6
Molecular Weight
559.64
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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