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NSI-189 Phosphate

CAT: 0013-GTR19156707-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156707-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSI-189 Phosphate is a novel neurogenic molecule with pleiotropic properties, including antidepressant, procognitive, synaptoplastic, and neurotrophic activities demonstrated in preclinical studies. Its antidepressant activity is monoamine-independent.NSI-189 actively stimulated remodeling of the stroke brain. Parallel in vitro studies further probed this remodeling process and demonstrated that oxygen glucose deprivation and reperfusion (OGD/R) initiated typical cell death processes, which were reversed by NSI-189 treatment characterized by significant attenuation of OGD/R-mediated hippocampal cell death and increased Ki67 and MAP2 expression, coupled with upregulation of neurogenic factors such as BDNF and SCF. These findings support the use of oral NSI-189 as a therapeutic agent well beyond the initial 6-hr time window to accelerate and enhance the overall functional improvement in the initial 6 months post stroke.
CAS Number
1270138-41-4
Product Name Alternative
NSI189 Phosphate, NSI 189 Phosphate, NSI-189 Phosphate
Purity
>98% (HPLC)
Solubility
DMSO:Soluble
Smiles
OP (O) (O) =O.CC (C) CCNc1ncccc1C (=O) N1CCN (Cc2ccccc2) CC1
Molecular Formula
C22H33N4O5P
Molecular Weight
464.5
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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