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MM-102 TFA

CAT: 0013-GTR19156687-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156687-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MM-102 TFA is a potent WDR5/MLL interaction inhibitor, achieves IC50 = 2.4 nM. MM-102 compound prevents the interaction between mixed lineage leukemia 1 (MLL1) and WD Trp-Asp repeat domain 5 (WDR5) and results in the inhibition of MLL1 H3K4 histone methyltransferase (HMT) activity. Down-Regulation of H3K4me3 by MM-102 Facilitates Epigenetic Reprogramming of Porcine Somatic Cell Nuclear Transfer EmbryMM-102, in bone marrow cells transduced with MLL1-AF9 fusion construct shows that the compound effectively decreases the expression of HoxA9 and Meis-1, two critical MLL1 target genes in MLL1 fusion protein mediated leukemogenesis. MM-102 also specifically inhibits cell growth and induces apoptosis in leukemia cells harboring MLL1 fusion proteins.
CAS Number
1883545-52-5
Product Name Alternative
HMTase Inhibitor IX TFA
Field of Research
Immunology & Inflammation
Purity
>98% (HPLC)
Solubility
DMSO:99 mg/mL (126.3 mM)
Smiles
OC (=O) C (F) (F) F.CCC (CC) (NC (=O) C (C) C) C (=O) N[C@@H] (CCCNC (N) =N) C (=O) NC1 (CCCC1) C (=O) NC (c1ccc (F) cc1) c1ccc (F) cc1
Molecular Formula
C37H50F5N7O6
Molecular Weight
783.83
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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