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Trans-C75

CAT: 0804-HY-12364A-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12364A-01Size:1 mg
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Description
Trans-C75 ((±) -C75) is an enantiomer of C75. C75 is a synthetic fatty-acid synthase (FASN) inhibitor.
CAS Number
191282-48-1
Product Name Alternative
(±) -C75
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Fatty Acid Synthase (FASN)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/C75-trans.html
Concentration
10mM
Purity
99.79
Solubility
DMSO : 83.3 mg/mL (ultrasonic; warming)
Smiles
O=C([C@@H](C1=C)[C@@H](CCCCCCCC)OC1=O)O
Molecular Formula
C14H22O4
Molecular Weight
254.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Rae C, et al. Inhibition of Fatty Acid Synthase Sensitizes Prostate Cancer Cells to Radiotherapy.|[2]Makowski K, et al. Differential pharmacologic properties of the two C75 enantiomers: (+) -C75 is a strong anorectic drug; (-) -C75 has antitumor activity. Chirality. 2013 May;25 (5) :281-7.|[3]Gao S, et al. Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci U S A. 2003 May 13;100 (10) :5628-33.|[4]Thupari JN, et al. C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci U S A. 2002 Jul 9;99 (14) :9498-502.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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