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6,7,4'-Trihydroxyisoflavone

CAT: 0013-GTR19156650-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156650-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
6,7,4'-Trihydroxyisoflavone, is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which has antioxidant, and anti-cancer activities.Molecular studies showed that 6,7,4'-THIF significantly inhibited acetylcholinesterase and thiobarbituric acid reactive substance (TBARS) activities in the hippocampus of scopolamine-induced mice.In addition, immunohistochemistry and Western blot results revealed that 6,7,4'-THIF significantly increased brain-derived neurotrophic factor (BDNF) and phosphor cAMP response element binding (CREB) in the hippocampus of mice. A single administration of 6,7,4'-THIF significantly improved scopolamine-induced cognitive dysfunction in these in vivo tests. Moreover, treatment with 6,7,4'-THIF alone enhanced learning and memory performance in the same behavioral tests. 6,7,4'-THIF improves cognitive dysfunction induced by scopolamine and enhances learning and memory by activation of the cholinergic system and the p-CREB/BDNF signaling pathway in mice.
CAS Number
17817-31-1
Purity
>98% (HPLC)
Solubility
DMSO:125 mg/mL (462.55 mM; Need ultrasonic)
Smiles
O=C1C (C2=CC=C (O) C=C2) =COC3=CC (O) =C (O) C=C13
Molecular Formula
C15H10O5
Molecular Weight
270.2
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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