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β-Elemene

CAT: 0013-GTR19156603-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156603-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
β-Elemene is a natural product isolated from Curcuma wenyujin, with an antitumor activity and induce cell apoptosis.β-Elemene significantly inhibited the metastatic capacity of MDR gastric cells in vivo and in vitro. Mechanistically, β-Elemene regulated MMP-2/9 expression and reversed epithelial-mesenchymal transition. β-Elemene upregulated Cbl-b expression, resulting in inhibition of the EGFR-ERK/AKT pathways, which regulate MMP-2/9. β-Elemene upregulated Cbl-b by inhibiting miR-1323 expression. Numbers of metastatic tumor nodules were significantly decreased in the lungs of nude mice after β-Elemene treatment. β-Elemene inhibits the metastasis of MDR gastric cancer cells by modulating the miR-1323/Cbl-b/EGFR signaling axis.
CAS Number
515-13-9
Product Name Alternative
(-) -β-Elemene, Levo-β-elemene
Purity
>98% (HPLC)
Solubility
DMSO:50 mg/mL (244.68 mM; Need ultrasonic)
Smiles
CC ([C@H]1[C@@] (C) (CC[C@@H] (C (C) =C) C1) C=C) =C
Molecular Formula
C15H24
Molecular Weight
204.35
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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