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Eledoisin

CAT: 0013-GTR19156576-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156576-01Size:100 mg
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Description
Eledoisin is a specific agonist of NK2 and NK3 receptors.Eledoisin is an undecapeptide of mollusk origin, belonging to the tachykinin family of neuropeptides.Eledoisin increases the value recorded under basal conditions by 24.5±3.7%; this stimulation is significantly (P<0.01) lowered to 13.1±1.9% by the simultaneous presence of CP99994. The same protocol is also used to characterize the sensitivity of Eledoisin stimulation to 0.1 μM SR48968 or 0.1 μM SB222200. SR48968 significantly (P < 0.01) lower the stimulation by Eledoisin, while SB222200 has no effect. Eledoisin stimulation is reduced by CP99994 and SR48968, NK1 and NK2 antagonists, respectively.Eledoisin (0.1-1 nmol/kg) injected into rats produces a biphasic cardiovascular response that consists of an initial fall of systemic blood pressure (8-15 mm Hg) followed by a rise (20-22 mm Hg) . Intracerebroventricular injection of Eledoisin produces an enhancement of grooming and scratching behavior in mice.
CAS Number
69-25-0
Product Name Alternative
Eledone peptide
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
H2O:18.15 mg/mL (15.27 mM; Need ultrasonic and warming)
Smiles
CCC (C) C (C (=O) NCC (=O) NC (CC (C) C) C (=O) NC (CCSC) C (=O) N) NC (=O) C (CC1=CC=CC=C1) NC (=O) C (C) NC (=O) C (CC (=O) O) NC (=O) C (CCCCN) NC (=O) C (CO) NC (=O) C2CCCN2C (=O) C3CCC (=O) N3
Molecular Formula
C54H85N13O15S
Molecular Weight
1188.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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