Bradykinin (acetate)

Bradykinin (acetate) is an active peptide that is generated by the kallikrein-kinin system. It is a inflammatory mediator and also recognized as a neuromediator and regulator of several vascular and renal functions. Enzymatically produced from kallidin in the blood, it is a powerful vasodilator that causes smooth muscle contraction, and may mediate inflammation. It has a role as a human blood serum metabolite and a vasodilator agent. It is a tautomer of a bradykinin (2+) .Exogenous bradykinin markedly inhibited TF expression in mRNA and protein level induced by LPS in a dose-dependent manner. Moreover, the NO synthase antagonist L-NAME and PI3K inhibitor LY294002 dramatically abolished the inhibitory effects of bradykinin on tissue factor expression. PI3K/Akt signaling pathway activation induced by bradykinin administration reduced the activity of GSK-3β and MAPK, and reduced NF-x03BA; B level in the nucleus, thereby inhibiting TF expression.Intraperitoneal injection of C57/BL6 mice with bradykinin also inhibited the thrombus formation induced by ligation of inferior vena cava.

6846-03-3

>98% (HPLC)

CC (=O) O.C1CC (N (C1) C (=O) C2CCCN2C (=O) C (CCCN=C (N) N) N) C (=O) NCC (=O) NC (CC3=CC=CC=C3) C (=O) NC (CO) C (=O) N4CCCC4C (=O) NC (CC5=CC=CC=C5) C (=O) NC (CCCN=C (N) N) C (=O) O

C52H77N15O13

1120.26

Storage temperature: -20°C. Stability: ≥ 2 years