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Azumolene

CAT: 0013-GTR19156857-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19156857-01Size:1 g
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Description
Azumolene1.EU4093 (azumolene sodium) is a direct acting, skeletal muscle relaxant with structural similarities to dantrolene sodium in that the para-nitro phenyl group of dantrolene sodium is replaced by a para-bromo phenyl group. 2. The effect of EU4093 on the twitch of the intact rat soleus preparation is nearly maximal at a dose of 20 mg kg-1. This dose of EU4093 reduces the amplitude of the twitch to 31.9% of the control value. By comparison, dantrolene sodium reduced the twitch amplitude to 31.3% of the control value at a dose of 5 mg kg-1. 3. The contraction of intrafusal muscle as measured by the response of spindle afferent discharge was also reduced by EU4093. 4. The most significant difference between the effect of EU4093 and dantrolene sodium on the contraction of intrafusal muscle was that EU4093 had an appreciable depressant action at high stimulation frequencies at which dantrolene sodium had only a minimal relaxant effect on the intrafusal muscle contraction.
CAS Number
64748-79-4
Product Name Alternative
EU4093 free base
Purity
>98% (HPLC)
Solubility
DMSO:13.89 mg/mL (39.78 mM; Need ultrasonic)
Smiles
O=C1NC (CN1/N=C/C2=NC=C (C3=CC=C (Br) C=C3) O2) =O
Molecular Formula
C13H9BrN4O3
Molecular Weight
349.14
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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