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Mito-TEMPO

CAT: 0013-GTR19156250-02Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19156250-02Size:500 mg
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Description
Mito-TEMPO is a mitochondria-targeted superoxide dismutase mimetic. Mito-TEMPO with superoxide and alkyl radical scavenging properties. (In Vivo) :Mito-TEMPO (MT) greatly attenuates the increase in ALT activities and reduces the areas of necrosis at both time points, indicating that the protection by Mito-TEMPO is sustained until at least 24 h post-APAP. Mito-Tempo could induce secondary apoptosis in the late phase of APAP hepatotoxicity. Mito-Tempo induces secondary apoptosis after APAP overdose by inhibition of RIP3.
CAS Number
1334850-99-5
Purity
>98% (HPLC)
Solubility
DMSO:125 mg/mL (245.08 mM; Need ultrasonic) ; H2O:60 mg/mL (117.64 mM; Need ultrasonic)
Smiles
[O]N1C (C) (C) CC (NC (C[P+] (C2=CC=CC=C2) (C3=CC=CC=C3) C4=CC=CC=C4) =O) CC1 (C) C.[Cl-]
Molecular Formula
C29H35ClN2O2P
Molecular Weight
510.03
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

MitoTEMPO

an antioxidant

CAS Number1334850-99-5
PubChem CID139269842
Molecular FormulaC29H35ClN2O2P
Molecular Weight510.0
Topological Polar Surface Area33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Heavy Atom Count35
Formal Charge0
Complexity612
SMILES
CC1(CC(CC(N1[O])(C)C)NC(=O)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C.[Cl-]
InChI
InChI=1S/C29H34N2O2P.ClH/c1-28(2)20-23(21-29(3,4)31(28)33)30-27(32)22-34(24-14-8-5-9-15-24,25-16-10-6-11-17-25)26-18-12-7-13-19-26;/h5-19,23H,20-22H2,1-4H3;1H
InChIKey
WKKFJIJNGHNQQW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of MitoTEMPO
CAS: 1334850-99-5
CID: 139269842
Formula: C29H35ClN2O2P
MW: 510.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight510.0
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count6
Exact Mass509.2124681
Monoisotopic Mass509.2124681
Topological Polar Surface Area33.3 Ų
Heavy Atom Count35
Formal Charge0
Complexity612
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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